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The fluid-mediated formation of carbonates (from mantle silicates) leads to more reduced residual fluids when the starting COH-fluid has a composition to the reduced side of the CO2-H2O tie-line (Figure 7).
We believed that the introduction of drug-phospholipid complex which not only acted as a bridge of drug loading but also served as a control of drug release, could endow the drug not only to increase the drug loading content but also to prolong the drug release period, which might actually contribute to the improved therapeutic efficacy and the reduced side effects.
Additionally, the reduced side effects and multi-function properties of these Kampo formulations can be exploited.
Since adverse side effects of drugs are exaggerated in HCA, the reduced side effects with dendrimer conjugates and suggestions of neuroprotection offer promise for these nanoscale drug delivery systems.
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Low molecular weight conjugates of dextran have the advantage of reduced side effects, however its therapeutic potential is not optimum, due to its relatively short plasma half-life [ 21].
The design problem of imposing deeper nulls in the interference direction of uniform linear antenna arrays under the constraints of a reduced side lobe level (SLL) and a fixed first null beam width (FNBW) is modeled as a simple optimization problem.
With this background, it is evident the importance of identifying the LD that produces the greatest UO at the lowest dose with, possibly, reduced side effects and renal injury.
Implementation of techniques to spare normal tissue, such as conformal radiotherapy (vide infra), therefore allows a choice between (i) dose increase with a consistent level of side effects, or (ii) the same dose with reduced side effects (see Fig. 1).
Selective NR1-Gly antagonists have been claimed to reduce pain with reduced side effects [ 87, 88].
Lower dosage in the clinic could translate to reduced side effects, potentially increasing patient compliance and lower the risk of cancer recurrence.
Therefore, if appropriate candidates for Paclitaxel administration can be identified at the time of diagnosis, a high antitumour effect and reduced side effects may improve the therapeutic index of the drug.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com