Sentence examples for the reduced efficacy from inspiring English sources

Thereby, cancer cells accelerate the glycolytic flux and compensate for the reduced efficacy of aerobic glycolysis.

Our results suggest that PEM can impair mucosal immunity where IgA plays an important role in host protection and may partly explain the reduced efficacy of oral vaccines in malnourished subjects.

We could demonstrate that the reduced efficacy is not caused by the tumour growth-promoting effect of the higher peptide amount since unlabelled DOTA-PEG5k-Lys-BN (group B) did not induce tumour growth compared with the control group (Figure 5).

The novel mechanistic explanation developed in this paper not only reveals the structural requirements for receptor partial agonists, but it also negates the long-held mechanistic explanation that the reduced efficacy of receptor partial agonists is the result of partial activation of each individual receptor molecule being occupied by the partial agonist because of its "low intrinsic activity".

The reduced efficacy of i.v. CpG administrations compared to p.t. exposure is thus not due to timing aspects.

Therefore, we tested, in HEK-APP cells, whether the reduced efficacy of doxorubicin-induced apoptosis was due to an impairment of p53 apoptotic activity.

In mice treated with 1 mg/ml micafungin, cysts with typical morphologies were apparent (Panel i, arrow), which coincided with the reduced efficacy at this dose.

The reduced efficacy of i.v. administered CpG in the current experiments may therefore relate to the delay in which CpG-ODN reach the released antigens at the ablation site.

It has also been suggested that greater exposure to environmental mycobacterial antigens in tropical and sub-tropical latitudes might be responsible for the reduced efficacy of BCG vaccine trials in these regions [9].

Instead, selection is at least to some extent preserving the function of genes that are more costly to lose, despite the strongly reduced efficacy of selection on the neo-Y chromosome.

Recognition of these effects has promoted speculation that helminth infection contributes to the observed reduced efficacy of BCG, and increased susceptibility to tuberculosis, in tropical countries [ 3].