The primary tumours were analysed for the secondary mutations of the recurrences, which had been identified previously.
The study by Ho et al 22 also included nine patients who underwent LT after the first recurrence, which we call SLT, but the authors did not compare the survival rates of this group with the re-resection group.
However, it is worth noting that while the intra-pelvic recurrence seems to have evolved entirely from this ancestor, there is a region of the extra-pelvic recurrence which is more closely related to the other evolutionary branch of the tumor, which gives rise to P1, P2, P6 and, apparently deriving from the latter, ER3.
From a total of 158 patients fulfilling these criteria, we selected randomly a sample size of 133 patients, divided in two different groups of similar size and stratified with regard to the development of biochemical recurrence, which was the key variable of the study.
Continuous ECG monitoring has a high chance of providing a symptom vs. rhythm correlation during the next syncope recurrence, which is crucial for determining the mechanism and guide subsequent appropriate treatment.
The clinical and histological outcome 12 weeks after treatment appeared to be a reliable predictor of the risk of recurrence, which was most commonly observed during the first year of follow-up [ 20].
Since eventual cancer-related deaths do not affect disease-free survival calculation (rather, it is the diagnosis of recurrence which precedes death that counts), it was assumed that the remaining difference in DFS5 was attributable to differences in background mortality.
In case of biochemical relapse in prostate cancer the PSA elevation indicates the presence of disease recurrence which is usually located to the prostatic bed, to adjacent or distant lymph nodes, and to bone.
Few treatment options are available in HGGs at the time of recurrence which typically is local.
