The rationale is given for the development of a second class of water-soluble antifolate TS inhibitors that were deliberately engineered not to be substrates for FPGS.
In all reviewed studies, little or no rationale was given for the choice of model, and, while model choices did appear appropriate for purpose, it is advisable to include a justification or rationale for the choice of methods [24, 25].
Intervention Rationale assesses whether a rationale was given that suggests why the intervention may produce improvements in the outcome (empirical evidence, theories or logic models).
Besides a short notice in 28, basically no rationale was given for considered control conditions in any of the reviews.
Palmer was out with a handsome severance, a restructuring plan was announced, a strong strategic rationale was given, managers were selected from both organizations to head up critical functions on day one, and a realistic number of planned layoffs were announced.
In contrast, a North Carolina telephone survey of social encounters recruited almost 4000 participants from four pre-specified counties, but no specific rationale was given for their selection [ 20].
The detailed rationale is given in the supplementary data, but the affinity for modulator binding to the dimer would need to be several orders of magnitude higher than binding to the monomer for the data to fit (SI Figure S5).
No rationale is given for the number of states selected.
No rationale is given for the consideration of three core strategies or their significance relative to the others considered.
