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The rationale is based on the fact that similarly sized and configured particles could be used for cell based drug delivery to treat a host of degenerative and infectious disorders.
The rationale is based on excellent results in surgical series with MCA IAs [ 21, 25].
The rationale is based on the theory that exogenous glucose stimulates insulin secretion which shifts potassium into the cell.
The rationale is based on the findings that TGF-β activity is greatly increased both in the skin and in the circulation of patients with RDEB.
The rationale is based on the hypothesis of lowered cognitive reserves following perinatal adverse events which would lead to susceptibility for later damage.
The rationale is based on the concept that direct delivery into the CSF within the intrathecal space avoids crossing the blood-brain barrier and allows delivery of smaller doses than oral, intravenous, transdermal or epidural drug administration.
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The rationale was based on the biopsychosocial model of chronic pain and subsequent interdisciplinary pain management approach.
The rationale was based on the very high sensitivity and high NPV of joint testing for an extended period of three years [ 10– 10].
The rationale was based on studies demonstrating that gene biomarkers can be used as predictors of tumor cell responses to therapeutic treatments [ 13, 14].
The rationale was based on the beneficial effects on depressive symptoms in patients who had previously received VNS for seizures, but the exact mechanism of action was not known [ 26, 43, 49].
The rationale was based on existing evidence that this was the worst natural disaster event in the country's history: an estimated 350 persons are reported to have died [ 15, 16], while about 10% of the 10,000 affected people were resettled over 300 kilometres away in the Mutunda sub-county of the Kiryandongo district in Western Uganda [ 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com