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Based on the rationale for combining a tyrosine kinase inhibitor of VEGFRs with chemotherapy, the combination of sunitinib plus irinotecan might offer efficacy in this patient category.
What was the rationale for combining currencies?
This aspect further supports the rationale for combining a cholesterol-lowering drug such as a statin with trastuzumab to facilitate a relatively rapid turnaround time for the diagnosis of HER2-positive tumors via molecular imaging with full-length antibodies.
This review will describe the rationale for combining agents targeting these pathways with radiation, provide an overview of the current landscape in the clinical pipeline and attempt to outline the future steps.
This article describes the rationale for combining the traditional "segmented" embryofetal development study with the pre- and postnatal development (PPND) study into a single "enhanced" PPND study design in the cynomolgus monkey where a single cohort of animals is exposed throughout gestation and allowed to give birth naturally.
Taken together, these studies provided the rationale for combining CD40L with TLR agonists in the present study.
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The results of these studies have important translational implications and provide the rationale for combined treatment with chromatin remodeling agents and immunotherapeutic approaches for pancreatic cancer.
Differences in their efficacy to block synovial inflammation, bone erosion and cartilage destruction further strengthen the rationale for combined blockade of more than one proinflammatory pathway.
Some of the rationales for combining conventional therapies with biologic agents for psoriasis treatment have a historical basis in the treatment of psoriatic arthritis.
Research on the effect of PDT on the vasculature demonstrated that this treatment often results in the induction of angiogenesis, which is the major rationale for combining PDT with anti-angiogenesis therapy.
The authors offer the hope that new-targeted therapies will be developed and describe the strong rationale for combining these agents with pre-existing ones (e.g. hsp90 inhibitors with bortezomib).
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