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Enzymes are highly selective catalysts which accelerates both the rate and specificity of metabolic reactions.
Herein, we report on the effect of mismatches, sterics, and electronics on the rate and specificity of drug and probe release in both two and three component model systems, and on the stability of the prodrug linker in human serum.
ZFNs have been used in mammalian cells to increase the rate and specificity of gene alteration and transgenesis.
α2 houses the active site for nucleoside diphosphate reduction and additional sites that control the rate and specificity of nucleotide reduction by dNTP and ATP effectors.
When PIN1 and ABCB19 coincide on the plasma membrane, their interaction enhances the rate and specificity of auxin efflux, and the dynamic cycling of PIN1 is reduced.
They are highly selective catalysts which can greatly accelerate both the rate and specificity of metabolic reactions, which range from the digestion of food to the synthesis of DNA.
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Myles and Leung indicated that OPN cleavage by thrombin was dependent on both anion-binding exosites in thrombin that determined the rates and specificity of thrombin proteolysis [ 5].
We present here the comparative genomic analysis of these orthologous regions and haplotype variation mediated by LTR-retrotransposons, thereby depicting the nature, timing, rate and specificity of DNA changes observed in these regions during the speciation and diversification of these closely related Oryza species.
We, therefore, conducted a randomised trial to compare the positivity rate, detection rate and specificity of FIT (OC-Sensor micro; Eiken Chemical Co., Tokyo, Japan) screening at different cut-off levels with gFOBT (Hemoccult II; Beckman Coulter Inc., Fullerton, CA, USA) screening in an average risk screening-naive population.
In the test set, this validation showed an accuracy of 92.3%, sensitivity of 85.57% (true-poor prognosis rate) and specificity of 100% (true-fair prognosis rate) for all the left out samples (test samples).
Hilgerink et al. [ 93] factored in uncertainty regarding the included criteria by asking participants to rate the sensitivity and specificity of the pairwise judgments on a three-point scale; this yielded negative, average, and positive scenarios for the overall priorities.
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