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Then, the raised expression of musclin could lead the hypertension to be more serious.
Our results show that most (eight out of nine) synovial sarcomas clustered as a single group based on their gene expression portrait and that this cluster was characterised by the raised expression of a set of 48 genes.
The raised expression of the snoRNA in INI mice could impact on other genes not quantified in this study; indeed, mbii52 has been implicated in the splicing of a further five brain transcripts (Kishore et al., 2010).
Endothelial dysfunction occurs in early stages of RA and atherosclerosis as a response to the raised expression of chemokines and adhesion molecules, promoting the enhancement of vessel wall permeability.
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The biceps femoris muscle of offspring born to HF fed mothers demonstrated raised expression of the genes ENO3, PGAM2, FAT/CD36 and a reduction in GLUT-1, but there were no differences in either GLUT-4 (C = 1.0 ± 0.1; HF = 1.5 ± 0.5 (P = 0.12)) or CPT-1 (C = 1.0 ± 0.1; HF = 1.2 ± 0.1 (0.16)).
Thirdly, where hepcidin levels are raised, expression of the iron transport protein ferroportin in enterocytes is suppressed such that release of absorbed iron into the bloodstream is restricted.
Only in a few tissues, such as gills and muscle, did line 1 show raised expression of the transgene, e.g. a sevenfold higher transgene expression in the gills when compared with the other organs examined (Fig. 2A).
In our study, we could show that treatment of TGCT cells with HP-compounds raised the expression of the cell cycle-inhibiting molecule p21, which resulted in an S-phase arrest of the cell cycle.
Interestingly, the introgressed QTLs raise the expression of γ-zeins, which appear to be able to restore kernel hardness despite the reduced levels of α-zeins [ 7].
For example, raising the expression of the drug transporters, including ABC (ATP-binding cassette) drug transporters, that pump out chemotherapeutic agents is another potential mechanism, as ABC expression may be enriched for cancer stem cells [23].
ZnCl2 was able to raise the expression of the most abundant metallothionein, Mt2, in hypoxic ZnT8−/− mouse islets to levels similar to those of hypoxic WT islets (Fig. 6g).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com