The difference in the aggregation propensity between the folded and disordered protein regions becomes even clearer if we only consider the fully unstructured sequences in IUPs and not the whole protein (Figures 8E and 8F).
The result guarantees a sufficient overlap in the distribution of the propensity score between adopters and non-adopters.
In this application, matching is based on a constant radius expressed as the difference in the log-odds of the propensity score between treated and comparison cases.
Nonetheless, in each case, whether three or five strata were used, the first two moments of the propensity score between SU and GMW observations were compared within each strata to further check for adequacy of balance.
We observed no clinically important differences in covariates within fifths of the propensity score between patients exposed to sitagliptin and those not exposed.
This approach is similar to that described above, with 1 exception: The difference in the logit of the propensity score between treated and untreated subjects in the propensity-score-matched set was required to be less than a prespecified maximum.
The Mann-Whitney test was used to evaluate the comparability of continuous factors used to generate the propensity score between the two groups both prior to and after matching.
If it is used without replacement, then the quality of matched controls could be poor due to possible large differences in the propensity scores between the intervention unit, and the corresponding matched control [ 22].
Sequence-based prediction is based on the assumption that knowledge of the amino acid sequence alone might be sufficient to estimate the evolutionary history, overall structure and function, and the interacting propensity between two proteins.
Variation in the mortality propensity between hospitals is accommodated by assuming a normal distribution for ui with mean zero and variance τ.
