We do observe substantial numbers of proliferating cells in response to pancreatectomy and indeed Cdk4R24C seems to promote the proliferation process.
We hypothesize that this finding may be due, in part, to the somatic mutations that the cells have acquired during the proliferation process (Fig. 6). Figure 6: Hypothesis for the accumulation of somatic mutations.
Finally, an explicit model of the cell cycle controls the proliferation process, taking into account the presence or absence of various metabolites, sufficient space and mechanical stress.
An attempt was also undertaken to select and optimize medium components for the proliferation process of Enterobacter sp. LU1 bacterial biomass on minimal culture media with the use of waste glycerol as sole carbon source.
The Shh-VEGF-Notch-Hey2 signaling pathway controls the proliferation process, and experimental modulation of single components of this pathway alters etsrp+ cell numbers at the LPM.
The occasional occurrence of STRO-1+ cells with three nuclei (Fig. 5d, e) might be related to the rapidity of the proliferation process.
In order to indentify miRNAs that potentially drive the proliferation process in breast cancer we tested a subset of the HP vs. LP differentially miRNAs using high-throughput lysate microarray (LMA) screening technology [28].
This parameter was found to be similar in both groups (Figure 9C), indicating that the PI3K/AKT pathway is implicated in the differentiation but not in the proliferation process in the pancreatic ductal cells.
