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If Lim1 is a potential oncogene and it is expressed in the immediate common progenitor for photoreceptors and horizontal cells then it may be the progenitor that is the cell-of-origin, potentially explaining the presence of genetic markers for both photoreceptors and horizontal cells in retinoblastoma [35, 37].
Similar to previous observations in a set of long-term bottlenecked C. briggsae lines (Howe et al. 2010), in this study some ΔmtDNA types were detected in multiple independently evolved lines of the same strain, suggesting that these probably constitute preexisting heteroplasmic variants present in the progenitor that experienced differential segregation patterns among lab lines.
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But what happens to the progenitors that were already present at the start of ND? Do they complete their differentiation programme even in the absence of continued proliferation?
Actually, our laboratory is working quite intensively on the origin of B-1a cells and has shown that they arise from progenitors distinct from the progenitors that give rise to B-2 cells.
It has been shown that at least some of the progenitors that populate the SGZ of the postnatal hippocampus have their origin in the germinative fetal neuroepithelium lining the ventricular zone (Clarke and van der Kooy, 2011).
Previous studies showed that radial glia in the ventricular zone (VZ) of the developing neocortex are the progenitors that produce nearly all excitatory neurons (Kriegstein and Alvarez-Buylla, 2009).
Do the progenitors that exit cycle turn on MAP2 prematurely and then die?
(B-F ) Identified photoreceptors are overlaid with the progenitors that precede and coincide with them at the point when the photoreceptors first appear.
The Wnt1-cre stain expresses cre in neural crest cells, causing recombination in the progenitors that give rise to sensory neurons (Danielian et al, 1998; Le Douarin and Kalcheim, 1999).
It is interesting to speculate on the role of the Cbx5 protein (heterochromatin 1α) in the biology of the crypt progenitor that is amplified in Min-induced tumors.
If the genes were ancestrally derived from the cyanobacterial progenitor that gave rise to the primary plastids in red and green algae, a cyanobacterial outgroup should also be recovered.
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