The majority of the putative interaction partners from all pull downs belonged to the processes of trafficking and vesicle trafficking although the overlap between the individual pull downs was limited.
In the process of apical trafficking, an apical endocytic-recycling pathway of galectin-4 is required, that is to say, galectin-4 endocytosed into cells to transport glycoproteins back to apical surface (Stechly et al., 2009).
Aβ is generated in the process of intracellular trafficking of APP, which is type I membrane protein.
This suggest a general role for Eps15 and its family members in controlling membrane morphology during the process of intracellular trafficking.
The process of leukocyte trafficking from the microcirculation to the site of inflammation is a hallmark of the response that the host sets up on infection and/or ingestion of xenobiotic products (1).
The latter aspect is becoming an accepted view in the scientific community in parallel to the appreciation that several endogenous mediators could become operative in the microcirculation to produce an inhibitory effect on the process of leukocyte trafficking (2).
In our current work we report that galectin-1, a homodimeric adhesion molecule and carbohydrate-binding protein with affinity for β-galactosides, is linked with cell surface expression of integrin β1 and the process of integrin trafficking.
Because BFA treatment caused aggregation of FM4-64-labeled TGN/EE into BFA compartments, we reasoned that a BFA washout would allow us to examine the process of vacuolar trafficking from TGN/EE via PVC/MVB to vacuoles.
Chemokines and their receptors are known to play an important role in the process of leukocyte trafficking and homing, especially at sites of inflammation, infection, tissue injury, cell damage and malignant tumour growth.
The process of extracting traffic signs data including how True Positive (TP), False Positive (FP), and False Negative (FN) detections are handled is key to the quality of the developed inventory management system.
