Prior to this study, it was thought that the problematic side effect of diarrhoea associated with each of irinotecan, 5-FU and radiation would cause severe toxicity should the agents be combined, rendering the regimen too toxic for routine use.
David Allsopp, professor of neuroscience at Lancaster University said that the study had thrown up "very dramatic and highly encouraging results", but said that more research was needed to overcome the "problematic side-effects" and to prove the technique would be effective against other disease like Alzheimer's and Parkinson's.
Further studies might also help the search for ways to reduce the problematic side-effects that limit the usefulness of opiate drugs as medicines.
These extrapyramidal symptoms, the most problematic side effects of haloperidol, show evidence of familial clustering (Yassa and Ananth 1981; O'Callaghan et al. 1990; Müller et al. 2001), but their heritability in humans remains unestimated.
The ubiquitous use of smartphones has not only led to unprecedented levels of connectivity, but also raised the question about potentially problematic side effects such as phone-use while driving or phone-caused inattention in work or private settings.
It was originally sold as an over-the-counter cough suppressant that didn't have problematic side effects, like addiction (the irony) - while alternative treatments morphine and codeine did.
The latter is recommended by the ACCG when the other drug therapies have resulted in problematic side effects.
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However none of the 14 patients in this latest study experienced severe or problematic side effects immediately, despite receiving repeated doses of the drug.
But the independent research group led by Arnold Monto, professor of epidemiology at the University of Michigan School of Public Health in the US, and Stuart Pocock, professor of medical statistics at the London School of Hygiene and Tropical Medicine, found Tamiflu had problematic side effects.
