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The fact that 6 weeks after the probable exposure, C. cayetanensis DNA was still detectable in 13 persons corresponds to the known persistence of the parasite.
Several studies in the nineteen nineties reported the successful experimental transmission of BSE to sheep by both intracerebral and oral routes [ 2], the presence of BSE infectivity in sheep brain and spleen [ 3] and the probable exposure of sheep to feed contaminated with the BSE agent [ 4, 5].
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This suggests that probable exposure source information is more likely to be missing from transmission groups with a greater prevalence of subtype C virus, such as the black African heterosexual population.
The most probable exposure period was during the New York to Hong Kong flight, in the Hong Kong airport, or during the Hong Kong to Fuzhou flight.
Because the nurse was not involved in cleaning activities the most probable exposure route would be inhalation and not through skin.
Using the 2.5-day median incubation periods for influenza A(H1N1 pdm09, the most probable exposure period was from midnight to noon on May 28, which coincides with the final 6 hours of the New York to Hong Kong flight, waiting in the Hong Kong airport, and during the Hong Kong to Fuzhou flight.
To approximate the most probable exposure period for this apparent point-source outbreak, we subtracted the median incubation period for influenza A(H1N1 pdm09 (2.5 days) (8 – 11 ) from the 12-hour interval for onset of the median case (pm, May 30) (12 ).
An important aspect is that people rarely become infected from foxes, thus the most probable exposure is through dogs.
A Cox regression analysis with the boys' age as the time variable was performed to compare the occurrence of hypospadias and cryptorchidism in the "possible" and "probable" exposure categories using the baseline "unlikely" exposure category as reference.
Although not selected by the stepwise forward selection, manual addition of self-reported exposure to solvents produced a similar effect as in the univariate analysis (OR = 1.9; 95% CI, 0.9 3.9), but the influence of probable exposure to EDs was substantially smaller (OR = 1.3; 95% CI, 0.5 3.3) than when analyzed univariately.
The delay between probable exposure and onset of symptoms was 3-10 days (mean ± standard deviation 6.1 ± 1.9 days).
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