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The company also set up a funding mechanism for projects inspired by venture capital processes: projects were funded in phases and progressed to the next phase only if it proved its worth in the prior phase.
Finally, Larry E. Greiner proposed a model of corporate evolution in which business organizations move through five phases of growth as they make the transition from small to large (in sales and employees) and from young to mature.|| Each phase is distinguished by an evolution from the prior phase and then by a revolution or crisis, which precipitates a jump into the next phase.
Results of the prior Phase 1a trial of RiVax were published in the journal Proceedings of the National Academy of Science of the USA.
However, a larger number of children were involved in the prior phase (identification of potential items through semi-structured interviews) [ 12].
In fact, the nephrectomy in the TIVO-1 study was an upfront criteria because it was based on the extension of the prior phase II study (Nosov et al, 2012).
First, in the prior phase III trial, 10 of 120 (8%) subjects in the NovoTTF-100A cohort and nine of 117 (8%) subjects in the BPC cohort had prior low-grade histologies 11.
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The selection of the tofacitinib 10-mg BID dose was based on the prior phase-2 and phase-3 studies of tofacitinib in RA.
Discussions concerning the progress made by incorporating strategies identified in the prior phases of the project were shared among the group.
38 The study itself represented somewhat of a paradigm shift, given the absence of prior phase II studies assessing cabazitaxel specifically in the setting of prostate cancer.
Fluid inflow during phase 3 is dependent on the hypertonicity developed during the prior loading phase 1 and unloading phase 2 periods.
Some of the limitations of this technocratic approach resulted from the poor implementation of the prior institutional phase.
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