Sentence examples for the prior pathway from inspiring English sources

The method of calculating the score is presented in algorithm 1. Step 4: If the score is significantly lower than the maximum possible score (L(L+1)/2) and the number of inconsistencies is higher, return to Step 1 to change the regulators that were undetermined from the prior pathway knowledge.

It also introduces the pre-processing PERA step, which improves the inclusion of prior pathway knowledge by making it more systematic.

The consistency of the derived pathway networks with the prior model pathway information was evaluated as follows: given an edge in the derived network we assigned it a binary weight (1,-1) depending on whether the correlation between the two genes is positive (1) or negative (-1).

Unlike Chuang et al [18], who use prior pathway knowledge to examine the plausibility of a pathway's involvement, all assessment of biological interpretation in our methods is retrospective; we first construct a network, then examine its structure to identify highly-connected sub-graphs and take these groups of genes to look for common biological roles.

Both the activation barriers and kinetic results demonstrate that Path A is the prior reaction pathway.

Being a computational approach based on the prior knowledge, pathway enrichment analysis is widely used in the study of genotype-phenotype associations [ 1].

In this study, we also incorporate prior pathway information from signaling databases to narrow the parameter search space and improve the accuracy of the models.

It was found that the use of log counts when normalized for sequence depth is a good strategy for data transformation prior pathway analysis.

The new method naturally deduced the shortest heuristic [ 5] but did not require the prior information of pathway structure or pathway length.

The results suggest that our method can predict the pathways without the prior information about the pathway structure and pathway length.

First, it depends on the prior knowledge of pathways which are far from complete, and identifying new pathways is a difficult, time-consuming, and labor intensive work.