Sentence examples for the prior functional from inspiring English sources

However, most of the currently available methods utilize the prior functional (GO) information to generate pre-defined sets of genes [17], [18].

Built upon diverse integrated biological knowledge, this framework directly models both the prior functional information and the association significances emerging from GWAS to optimally highlight single nucleotide polymorphisms (SNPs) for subsequent replication.

It has been previously demonstrated that integrating the prior functional information (e.g. GO) can contribute to the identification of functional modules [ 50, 52- 54].

The strong prior functional and genetic evidence for the role of WNK1 in BP regulation [11] together with replication in additional populations, provides further support for the role of WNK1 in BP regulation in both hypertensives and the general population.

This may also have affected the low representation of the BP loci with prior functional evidence among the top results in previous GWA studies.

8 Additional patient factors, such as prior cognitive function, prior functional ability and comorbidities are also likely to influence decision-making.

The ANN has the advantage that no prior functional form is needed (Derras et al. 2012): the actual dependence is established directly from the data and can therefore be used as a guide for a better understanding of the factors which control ground motions.

Third, though the authors adjusted for severity of illness, it is possible that unmeasured patient characteristics not captured by APACHE III, such as complexity of the surgical procedure or prior functional status of the patient, differed between groups.

As noticed in [ 4], the accuracy of machine-learning algorithms for AFP tasks is negatively affected by the sparse coverage of experimental data and by the limited availability of prior functional knowledge.

These methods not only facilitate the selection of variants with prior functional support for subsequent follow-up studies, but crucially, they propose biological mechanisms underlying the identified genotype-phenotype associations.

The rationale is similar to that of the traditional 'candidate gene approach' in principle, where prior functional information is used to effectively limit the number of association tests and thereby to increase power.