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Cystic fibrosis is a complex disease and it is well recognized that although the principals underlying the genetic and functional defects in CFTR have been identified, two individuals with the same CFTR genotype may follow a different natural history and trajectory of their lung disease.
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In an exhibition whose scope is so vast, the principal underlying concepts are obviously diversity and variety.
It's a formula that harnesses persuasive gender myths with an action agenda blind to many of the principal underlying causes of women's disempowerment.
The principal underlying cause is non-orthologous gene displacement (NOGD) whereby the same essential function is performed by unrelated or at least not orthologous genes [ 9].
After excluding 10924 cases with missing ICD-10 codes, the principal underlying causes of renal failure were hypertension (20.4%), diabetes mellitus (12.0%) and glomerulonephritis (7.7%).
These differences significantly influence gene expression and that operant variability compromises the results obtained by microarray analysis as well as the confidence to identify the principal underlying immune mechanisms.
The principal underlying force of the inflationary phases of evolution is extensive genetic exchange between the respective biological entities, taking the forms of recombination, fusion, and fission; the specifics of these processes differ for different inflationary stages.
For DM/PM, respectively, as associated causes, the following were the principal underlying causes of death: respiratory disorders (in 28.3%/26.0%); circulatory disorders (in 17.4%/20.5%); neoplasms (in 16.7%/13.7%); infectious and parasitic diseases (in 11.6%/9.6%); and gastrointestinal disorders (in 8.0%/4.8%).
Unlike embryos injected with the SpRunt-1 MASO alone, most of the morphants coinjected with solutions containing 400 800 ng/μl of SpPKC1 mRNA gastrulated and displayed negligible TUNEL signal, indicating that underexpression of PKC is indeed the principal underlying cause of the apoptosis and resulting gastrulation defects associated with SpRunt-1 deficiency.
The fundamental principal underlying the utility of this approach is that biological effects can be compared through the corresponding transcriptional changes.
Cancer-specific deaths were determined as a first, or principal underlying cause of death with International Classification of Disease (ICD) 10 codes for colorectal cancer, C18 to C20, as well as C26 and C80.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com