Sentence examples for the principal defect from inspiring English sources

But Mr. Cooper of GQ said the impulse to reduce everything to a cartoon was the principal defect of magazines like Stuff.

That year Goldsmith devoted a whole issue to his 'Blueprint for Survival' which began: "The principal defect of the industrial way of life with its ethos of expansion is that it is not sustainable".

At pressures of 12 and 20 GPa, the structure consists primarily of dislocation cells; at 40 GPa, twinning and stacking-fault bundles are the principal defect structures; and at a pressure of 55 60 GPa, the structure shows micro-twinning and the effects of thermal recovery (elongated sub-grains).

The principal defect of this account is that it makes the belief component of intention epiphenomenal.

The fact that exogenous αSNAP can rescue acrosomal exocytosis in these cells is a strong evidence that the principal defect is a malfunction in the endogenous protein.

Our data suggest that the principal defect in the disease could be the inability to respond appropriately to oxidative stress.

Our model has also allowed us to identify altered calcium handling as one of the principal defects contributing to ventricular dysfunction in this model, and a potential target for therapeutic manipulation.

By restricting their prohibitions to the D&X procedure exclusively, the Kansas, Utah, and Montana statutes avoid a principal defect of the Nebraska law.

Spectrin deficiency of varying degrees is common in HS and probably represents the principal structural defect leading to loss of surface membrane.

Mutations in the hABCD1/ALDP gene are the principal inherited defect in adrenoleukodystrophy, a clinically heterogeneous X-linked recessive disorder characterised by adrenal insufficiency and neuronal demyelination [ 57].

Their principal defect seems to lie in a lack of fine control over the muscles of the throat and mouth, needed for rapid speech.