The absence of strong positive regulators in our RNAi screens suggests that the primary regulation of TRAIL-induced apoptosis is by inhibition of the TRAIL pathway.
The main activity of glucagon involves the primary regulation of glucose production in the liver in situations of fasting, exercise and hypoglycaemia (Ramnanan et al. 2011).
Interestingly, deletion of HIF1α had no effect on the development of the retinal vasculature, suggesting that in retinal astrocytes, the primary regulation of VEGF expression is HIF1α-independent.
This is a strong statement about the primary regulation of cell wall growth, which we consider further in Discussion.
Taken together, these data suggest that the primary regulation of glycolysis in response to hypoxia in A. fumigatus may occur post-transcriptionally.
The primary regulation of PhPT1 by ethylene may also allow the plant to use the P in the corolla as a reserve during P starvation or other stresses that induce senescence.
The gene encoding ß catenin, CTNNB1, was not amongst the dysregulated genes identified in this analysis, consistent with the primary regulation of cellular ß catenin levels through post-translational mechanisms rather than transcriptional induction [ 27].
It was therefore inferred that changes in enzyme levels are not the primary regulation mechanism used by cells to, at equal flux, compensate for the loss of catalytic capacity at lower temperatures.
The primary regulation of systemic glucose levels by insulin is triggered when hepatic receptors recruit the insulin receptor substrate (IRS), leading to activation (phosphorylation) of PI3K/AKT and in turn phosphorylation of FOXO1, which blocks its nuclear translocation and inhibits activation of gluconeogenic genes (notably PEPCK and PC) to reduce net cellular glucose output [ 18].
Taken collectively, these data suggest that, of the target genes analyzed, ΔNp63 isoforms function as the primary regulator of transcriptional regulation.
