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At intervals ranging from 15 to 24 years after the primary demonstration of the M-component, all three patients presented with symptoms of multiple myeloma and died within less than one year after the disease had been diagnosed.
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We give a primary demonstration that the described dynamics holds not only for step-wise benefit function (strict threshold function), but for a wide range of sigmoid curves between the step-wise and the linear benefit functions (s-shape function).
The Primary Community Care Network (PCCN) Demonstration Project, launched by the Bureau of National Health Insurance BNHIin in 2003, is still in progress.
The Primary Community Care Network (PCCN) Demonstration Project, a nationwide healthcare financing program funded by the Bureau of National Health Insurance BNHIin in March 2003, aimed to change the behavior of outpatients by giving them the freedom to select their medical providers.
One health reform launched was named the "Primary Community Care Network (PCCN) demonstration project", a nationwide health care financing program funded by the Bureau of National Health Insurance BNHIin in March 2003 and it was a new model for the Taiwan government to redefine the role of family physicians in the health care delivery system.
This has resulted in recommendations by the regulatory authorities (e.g. European Medicines Agency, Committee for Proprietary Medicinal Products, CPMP/EWP/565/98) and by the World Federation of Neurology Committee on Research (Miller et al., 1999) that survival should be the primary endpoint for definitive demonstration of a neuroprotective drug effect.
The country has already created a one-million-member People's Armed Police, a paramilitary force with training in crowd control, as the primary bulwark against unruly demonstrations, and further growth in these forces is expected as well.
"In the case of Caracas, the middle class and college students are the primary actors in the demonstrations," wrote anarchist Venezuelan blogger Rafael Uzcátegui.
Further demonstration of the primary involvement of the extrinsic apoptotic pathway was assessed through evaluation of the expression of c-FLIP and Bid by western blot (WB).
Experiments performed with decellularized tissues, in which the ECM is preserved, represent a further and direct demonstration of the primary role of ECM in the regulation of stem cell properties.
Structures such as functional cell membrane protrusions have previously been shown to contain membranes of increased order, such as the demonstration that the primary cilia in epithelial cells possess a lo domain at their base [41].
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