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Overall comment: This is a well-written paper on an important topic, for which there is limited data: What is the prevalence below which routine screening of all pregnant women for HIV and, in particular, syphilis is no longer advisable?
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However, until the prevalence dropped below 0.5%, substantially below the reported HIV prevalence among TB patients in any setting in India, the cost-effectiveness ratio for Strategy 3 (routine referral) remained less than 3x the per capita GDP in India, $3,050/YLS (Figure 1).
To examine average prescription gross margin (GM) for prescriptions and to evaluate the prevalence of below-cost reimbursement for generic prescriptions across different third-party payers and therapeutic categories.
We calculated the prevalence of below average, borderline or poor (below the 25th percentile) HFD.
To compensate for this non-perfect sensitivity, a low value of 1% was chosen for the design prevalence, below the range of 5 30% reported in published studies [ 32].
Endemic and disease-free states are separated by an unstable equilibrium that represents the critical prevalence below which the system converges to the disease-free state.
The population size simulated was N = 100,000 and therefore the prevalence threshold below which scrapie was considered eradicated was 0.001%.
Since no HPAIV H5N1 was detected during this period, it can be implied that the prevalence was below the respective threshold value in the area.
When the prevalence is below 10−4, both 1- and 2-dose programs would contain the pandemic.
For example, in Somalia and Gambia the prevalence is below 2%.
When the prevalence is below 0.07% only tests with specificities of 99.995% provide reasonably accurate identification of the disease [ 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com