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In fact, in the present trial, even though patients were being treated according to current evidence-based standards (Table 1), both adiponectin and PAI-1 presented an unfavorable evolution along the trial in the placebo group.
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As a matter of fact, the occurrence of severe bone marrow toxicity was even lower in the present trial than in our previous study (Frasci et al, 2000), in which full doses of gemcitabine (1200 mg m−2) plus vinorelbine (30 mg m−2) were administered from the beginning, while dose-reduction rules during treatment were exactly the same.
A trial, even though under-powered as is the present trial, can give important clues concerning such mechanisms by analysing clinical responders both in completers and non-completers.
The present trial clearly demonstrates that such transitioning is safe and well tolerated, even by patients with inverse ratios approaching 4 1.
The present trial shows that nystatin pre-emptive therapy in surgical/trauma ICU patients significantly reduces fungal colonisation, even in those colonised at admission.
The present trial showed that oral nystatin prophylaxis started on the day of admission is significantly effective in reducing heavy fungal colonisation, even in baseline colonised patients.
The present trial is a phase IIb efficacy assessment trial.
The present trial started 1. September 2008.
Previous entry in the present trial.
As it is presented at trial, even normal science is integrated into an advocacy narrative and becomes unmoored from the discourse of science as practiced outside the litigation context.
There are legal rules that prohibit evidence from being presented at a trial even though it is relevant to a factual proposition that is material and in issue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com