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The preliminary structure activity relationship studies identified some important structural features considerably influencing the biological effect deserved, providing valuable information for chemists and pharmacologists to design and synthesize more effective antitumor agents bearing the 9,11-secosteroid 9,11-secosteroid
We here report the preliminary structure activity relationship (SAR) studies of this novel lead compound.
In order to discover more potent inhibitors and explore the preliminary structure activity relationship, a series of unique stereodimers of sinomenine analogues were designed and synthesized.
From Table 2, the preliminary structure and activity relationship (SAR) analysis indicated that compound with electron donating group at para position of benzene ring exhibited significant antifungal activity against SL.
The preliminary structure and layout of key components including ion sources, neutralizers, ion dumps, deflection magnet, beam edge scraper, long pulse calorimeter target, short pulse calorimeter target, injection port and beam drift duct are determined.
9. Based on the preliminary structure, examine the NOESY spectrum and assign any ambiguous peaks.
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The preliminary structure-activity relationship (SAR) was discussed in detail.
The preliminary structure-activity relationships were also summarized.
The preliminary structure-activity relationship (SAR) of these new compounds was investigated, which may help designing more potent molecules.
The preliminary structure-activity relationships as well as molecular docking disclosed that 1H-imidazole-4-carboxamido as a linker was of great importance for the antitumor activity.
The preliminary structure-activity relationship (SAR) of this new series of compounds was investigated, which may help designing more potent molecules.
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