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The predominant consequence of this accumulation is the activation of proto-oncogenes or silencing of tumor-suppressor genes [ 58].
Unexpectedly, the predominant consequence of c-Myc activation was shown to be the widespread repression of miRNA expression, probably as a direct result of c-Myc binding to miRNA promoters [ 73, 89].
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Thus, we rather interpret the PE reduction in psd1Δ and psd2Δ as a predominant consequence of their primary loss of enzymatic function and not as a result of the dead cell population.
As a consequence, the predominant effector T-cells in the TME are presumably constituted of low avidity OA-specific T cells whose activity is inhibited by Tregs that first expand in the spleen and tumor draining lymph nodes during cancer progression and in TME in later phases [ 100, 132, 133].
Similar to U2OS and Cl2 6 cells there was no major change in p53 protein level in cells treated with RPS9 siRNA (Figure 7E), but we found that p21 protein was reduced in RPS9 knockdown HeLa cells, presumably as a consequence of the predominant apoptotic response.
As a consequence of the predominant use of anti-RAS versus other drugs, only a mild decline of BP values from the referral visit was observed.
In cirrhosis, as in heart failure, arterial underfilling, and its ensuing consequences, are also the predominant hypothesis behind the physiopathology of hyponatremia [201].
Amongst the predominant work stressors that can have consequences outside the work situation are interpersonal stressors [6] and emotion management (suppressed expressions of emotion at work) [7].
In cirrhosis, as in heart failure, arterial underfilling, and its ensuing consequences, are also the predominant hypothesis behind the physiopathology of hyponatremia [ 201].
In BFR composites, the predominant damage mode was determined to be fiber breakage as a consequence of experiments and SEM analyses.
In this context, the predominant use of traditional pedagogies has a number of counterproductive consequences.
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