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It's the powerful reason why you want to do something; your overarching purpose.
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As Diderot later pointed out in his Letter on the Blind, for Condillac to rest his case against scepticism about the existence of an external world on such facile grounds was to ignore the powerful reasons for denying the existence of material things that had been articulated by Berkeley.
And there's the cost, perhaps the most powerful reason for the failure (or refusal) to run long-term clinical trials, and the NHS's dogged refusal to relax its position.
The most powerful reason the church is struggling in North America right now is that the church's way of being in the world does not represent a genuine alternative to the norms of the culture.
According to a study published in the current Academy of Management Discoveries, the most powerful reason people work from home is not that it makes family life easier or saves on a commute, it is because others are doing so.
Millions of bitter experiences like those of the Soros family were the most powerful reason Europeans vowed never again, and embarked on their ambitious unification project.
Arguably, the most powerful reason for blaming ETA is the timing of the attack - just three days before a Spanish general election.
The most powerful reason for rejecting epiphenomenalism is the view that it is incompatible with knowledge of our own minds — and thus, incompatible with knowing that epiphenomenalism is true.
But she was the most powerful reason that he survived.
Here is the first powerful reason why fewer applications from wind farms are being accepted by planning committees than in the past.
Perhaps the most powerful reason for an artist to make music is its direct appeal to the emotions, and the body; art – particularly conceptual art – is more cerebral.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com