Sentence examples for the potential checkpoint from inspiring English sources

Despite the importance of asymmetric divisions in the development of multicellular organisms, the potential checkpoint mechanisms that ensure asymmetric cell divisions, similar to the SPOC in the budding yeast, are poorly defined.

Our results also raise the interesting speculation that while in plants the high GC content of the gene may be a major obstacle for translation while in mammalian cells, normally growing at a much higher ambient temperature (typically 10°C to 20°C higher) the region provides for yet another potential checkpoint for the highly complex regulation of ACHE gene expression in mammals [ 60].

Gao, A., Sun, Y. & Peng, G. ILT4 functions as a potential checkpoint molecule for tumor immunotherapy.

Another potential checkpoint combination therapy might include blockade of PD-1 and LAG-3, a molecule also involved in the regulation of T-cell activation.

In humans, an understanding of the potential role of these checkpoints for selftolerance is based on the analysis of Ig genes cloned from single purified B cells at different stages during their development [ 12, 13, 42- 44].

Breaking tolerance at the tumour site is a potent phenomenon and the potential for synergy with other checkpoint inhibitors such as ipilimumab have also been demonstrated in 2013.

Gene analysis has proven to be new approach for judging the potential clinical benefit of immune checkpoint inhibitors, such as mutational landscape and mismatch-repair deficiency.

A number of investigators have demonstrated the potential advantages of combined immune checkpoint inhibition therapy and external beam radiotherapy [9 11].

This isn't fool-proof (what if you get pulled aside for additional screening while your stuff sits exposed on the conveyor belt?) but it should significantly reduce the potential for "shrinkage" at the checkpoint.

To explore the potential of Cdc14 as a checkpoint regulator, we therefore analyzed its impact in a setting where mitosis is delayed in cells that fail to establish tension between sister chromatids as a result of defective sister chromatid cohesion.

Alternatively, a therapeutic agent that could reactivate a checkpoint has the potential to re-enable the cell to detect and respond to DNA damage by senescence or cell death.