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Clinical heterogeneity was assessed in the population, methodology, and in the intervention and outcome measures of each study to evaluate whether pooling of results was feasible.
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21 77 Study design, selection of the study population, methodology used as reference standard and administrative data specifications varied greatly.
Therefore, inconsistencies between our findings and previous studies are partially due to the difference in population, methodology, assessment tools, statistical analysis, and small samples of some variables in this study.
Furthermore, if there might have been transmitted mutations, the population sequencing methodology that we employed might have left out mutations that occur as minor populations.
The population analysis methodology used in the present study differentiates between structural variability (within an individual) and random variability (between individuals).
Discrepancies in these findings may be due to differences in the study populations, methodology, and/or ages of the offspring at the time of outcome assessment.
When ADAS-cog, MMSE and CDR-SB items are considered, similar item combinations are identified as responsive to disease progression despite the diversity of the populations and methodology, indicating that the majority of MCI subjects in clinical studies have a common symptom profile over time.
The fruitful fusion of preclinical and population methodologies promises increasingly personalized and mechanistic approaches.
Whereas the results of this analysis are specific to the British population, the methodology can be applied to other populations.
However, prevalence estimates varied considerably across some studies, depending on the population and study methodology.
The haplotypes were determined for each RIL individual in the population with the methodology of Truco et al. (2013).
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