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The point of testing drugs for approval is to identify which patients might benefit and see if they do, not to assume that some patients somewhere might.
On the point of testing for neutrality, I started to think hard about this two or three years after Kimura's paper came out, and this resulted in my 1972 paper "The sampling theory of selectively neutral alleles".
The LTUQ was structured around a core questionnaire that assessed the extent and nature of tobacco use from earliest exposure to the point of testing.
Informants noted that students often work on faculty members' research projects, but some informants indicated they try to get the students to the point of testing their own hypotheses.
So what's the point of testing?
Bethe agreed entirely with Vannevar Bush that, by taking the H-bomb project through its theoretical and engineering phases to the point of testing, but without carrying out a test, the US could open a way to control.
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Baseline SpO2, nadir SpO2 (the lowest SpO2 during the test) and end-test SpO2 (the SpO2 at the point of test termination) were recorded.
During the last 10 s of each exercise stage and at the point of test termination, heart rate was measured from a 12-lead ECG, and rating of perceived exertion (RPE) was obtained using the Borg 15-category scale (10).
Blood pressure was measured during the last 45 s of each even minute exercise stage (i.e., stages 2, 4, and 6) and at the point of test termination.
The limitations of this study included that biomechanical and histological results were only reported at the terminal point of testing.
Focus was set on the Point-of-Care Testing (PoC).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com