This does not condemn such analytic approaches, but the point remains that there is much of importance that 'falls through the cracks' in such analytical treatments, particularly since a pivotal objective of many forms of design research is to account for design activity.
Russian military officials said the forces had taken some pivotal objectives, including a bridge over the Sunzha River.
Those who had already received a trastuzumab-based regimen during the pivotal trial had a 11% objective response rate and 22% clinical benefit rate.
7, 46 Given the aesthetic aspects of treating hypotrichosis of the eyelashes, which can be highly personal and extend beyond objective measurements, the pivotal trial also included patient-reported outcomes (PROs) as measures of efficacy.
Researchers found that the group of patients who had previously received chemotherapy alone during the pivotal trial had a 14% objective response rate and 32% clinical benefit rate (CR plus PR plus stable disease for ≥ 6 months) during the extension trial.
The study clearly establishes the pivotal significance of perusing true multi-objective optimization strategies commensurate with the increasing need to address the emission-performance trade-off challenges of the diesel engines of the day.
The pivotal role of androgens and the AR in prostate biology prompted this study with the objective of identifying molecular mediators of androgen action.
With our revised SPA, the FDA has agreed that the pivotal ADAPT study could support a future Biologics License Application (BLA) submission if the study objectives are met".
The objective of this analysis was to assess SSEs as a prespecified exploratory end point in the pivotal phase III trial of denosumab versus zoledronic acid in patients with castration-resistant prostate cancer and bone metastases.
The pivotal phase III study comparing best available standard therapy versus best available plus Herceptin demonstrates that this new biological agent improves objective response rates by 54%, response duration by 58% and time to progression by 65%.
