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Subsequently, the pGP of the remaining pair of samples (e.g. one time-segment from a patient and one from a control in one condition or the time-segment from the 97% contrast condition and one from the 8% condition from the same subject), which was so far unseen by the algorithm, was calculated.
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Pallis and co-workers have developed sensitive and robust methods for the reproducible measurements of PGP in AML blasts permitting classification of the PGP status of AML patients in the clinical practice.
One US academic used the example of the PGP to argue earlier this year that informed consent by participants needed to be matched by usage agreements by anyone accessing the data.
However, the influence of such environmental factors on the PGP potential of root-associated bacteria is poorly understood.
Reproducible methodology has been developed to determine the PGP status of AML patients permitting the routine phenotyping of these patients.
Table 5 represents a compilation of remission data, from studies in which the Pgp status of patients is known.
Like in the PGP Web of Trust, users are required to define social relationships, i. e., determine to which extent they trust particular users (user trust level).
Where cells were available, we measured the Pgp status of primary AML samples (31/34 samples, 9 Pgp positive and 22 Pgp negative, Tables 1 and 2).
Sub-toxic doses of the Pgp inhibitor CSA and also of the BCRP inhibitor FTC were added to cell culture with 10-1000 nM barasertib-hQPA.
This rapid and efficient efflux is similar to that of the Pgp substrate Rho123 from mitochondria of a drug-resistant hepatocellular carcinoma cell line (Solazzo et al, 2006).
We compared the Pgp inhibitory activity of tipifarnib with the more commonly used Pgp inhibitors, cyclosporin A, vinblastine and verapamil.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com