Examination of let-7's involvement in late histogenesis by the perturbation of function approaches revealed that let-7 facilitated differentiation of both neurons and MG, without preference to a particular lineage.
Attention has, therefore, been focussed on the normal functions of common fragile site genes, as it is the perturbation of these functions that is most likely to contribute to cancer.
Different from these works, we will not only consider the perturbation of objective functions but also consider the perturbation of feasible sets.
Recently, Tan et al. [23] proposed the generic stability of Ky Fan's point with respect to the perturbation of inequality functions equipped with the sup-norm metric.
This raises the possibility that the clinical phenotypes of CdLS individuals with NIPBL mutation might result from the perturbation of a function of NIPBL that is independent of its role in cohesion or cohesin biology.
The generation of specific reporters of gene expression history, and the perturbation of gene function [131] will allow for a greater understanding of how the retina develops.
One of the first examples demonstrating the essential nature of proper cell cell contacts involved the perturbation of cadherin function.
Given the perturbation of electrical function observed in hadp1 morphant hearts, we turned our attention to Ca2+, a major effector of muscle contraction, and thus cardiac contractility.
The incorporation of 14C-leucine into rabbit lung slices was monitored in the absence and presence of selected drugs and chemicals relevant to the perturbation of lung function and the development of lung disease.
The key role of GalT-II in GAG synthesis and the crucial biological functions of PGs are consistent with the perturbation of many physiological functions that are critical for the correct architecture and homeostasis of various connective tissues, including skin, bone, cartilage, tendons, and ligaments, and generates the wide phenotypic spectrum of GalT-II-deficient patients.
