Sentence examples for the perk from inspiring English sources

With the development of GSK2606414, an ATP competitive small molecule inhibitor of the PERK kinase activity, pharmacological intervention upstream in the PERK signaling pathway became feasible [ 3].

Treatment with the PERK inhibitor ameliorated neurodegeneration similar to the genetic interventions in the PERK pathway [ 64].

As both CHOP and GADD34 are components of the PERK pathway, the earlier up-regulation of these two genes suggests an earlier onset of the PERK pathway.

The Perk!

Tenants like the perk.

He terminated the perk immediately.

First, we examined the activation of the PERK-eIF2 α-ATF4 axis.

We conclude that ISRIB specifically blocks signaling of the PERK-branch of the UPR.

Disruption of the PERK-BiP complex results in dimerization, autophosphorylation and activation of the kinase domain of PERK.

a Treatment with PKM2 siRNA significantly reduced the pERK/ERK and pSTAT3/STAT3 ratios.

In ERK1/2 immunoprecipitates as well as in KSR1 immunoprecipitates, the pERK tERK ratio is not significantly different from the pERK tERK ratio in the input samples.