Sentence examples for the patterns of modification from inspiring English sources
However, the great majority of bulk histones analysed by western blotting or microscopy, are derived from intergenic chromatin and the patterns of modification observed will not necessarily reflect those present across individual genes.
Certain chromatin modification clusters in H appear to be analogous to ones in IMR90 based on the patterns of modifications, such as the "enhancer-like" state 1 (H) with state 1 (IMR90), and the "promoter-like" state 5 and state 6 (H) with state 2 (IMR90).
Primers corresponding to 150 kb from the Xq centromere-arm boundary were also included (site 9) to address symmetry of the pattern of modifications and to assess chromatin environment outside the centromere.
We have analysed the pattern of modifications mediated by CRISPR/Cas method.
These modifications can control gene expression and the pattern of modifications is altered in many cancers (211, 212).
It is interesting to compare the pattern of modifications on target RNAs of N. crassa to those described in the two yeasts, S. cerevisiae and S. pombe.
Recently, it was shown that the proline isomerase Fpr4 targets H3 P38 to alter the pattern of modifications at K36, thereby altering gene expression (42).
These data indicate that X chromosomes in the sexes differ by degree of modification, but the pattern of modifications along the male X chromosome is shadowed along the female X chromosome.
As histone modifications and cytosine methylation play a role in the activity of genes, aberration in the pattern of modifications to histones and DNA, called epigenome, can lead to disease.
It is therefore often necessary to use eukaryotic expression systems to produce correctly processed proteins, but even then the pattern of modifications is usually different from the natural situation.
A unifying concept central to a modern, molecular view of epigenetics postulates that the pattern of modifications (both of DNA and of histone proteins themselves) provides information content that instructs the enzymes integral to nuclear physiology (Jaenisch and Bird 2003; Strahl and Allis 2000).
