Moreover, depending on the loci of mtDNA cleavage, the pattern of dysregulation of mitochondrial proteins in early response to mtDNA cleavage differs.
In order to understand the underlying genetic and molecular mechanisms that contribute to CBA-dependent SKM wasting at end-stage SIV, we previously examined the pattern of dysregulation of several key genes involved in biological processes required for SKM homeostasis [ 13, 14, 16].
We examined the kinetics of dysregulation of several cell cycle regulatory genes by BAY 2402234.
Taken together, these results support the importance of dysregulation of IAPP metabolism in T2D in East Asians.
The pattern of hypothalamic dysregulation of GRP78 in PGC-1β KO as compared to WT mice, i.e. higher in chow fed mice and unresponsive to HFD stress was also reproducible in the cortex in vivo and also in cortical neurons in vitro, respectively (Fig. 2D).
The pattern of microRNA dysregulation suggests that GM may further progress to IM.
The pattern of miRNA dysregulation from CTT samples was similar when compared to both D-NT and N-NT controls.
It has been shown that patients who survived early psychosocial stress, as well as a wide range of mental disorders, show change in the patterns of NR3C1 methylation and dysregulation of HPA axis.
We hypothesized that immune mediator concentrations in the bronchoalveolar fluid (BALF) are predictive of bronchiolitis obliterans syndrome (BOS) and demonstrate specific patterns of dysregulation, depending on the presence of acute cellular rejection, BOS, aspiration, and timing of lung transplantation.
These studies showed tissue specific, and gene specific patterns of dysregulation, with enrichment for specific pathways (notably oxidative stress response in the heart and adrenal gland).
