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Once signatures are identified, the patterns of altered gene expression induced by unknown agents might identify their likely mechanism of action.
This suggests that the patterns of altered representation identified in this study are not limited to reorganisation of body-part representations in the primary sensorimotor cortex.
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The aim of this study is detect the pattern of altered cerebral perfusion at interictal stage of episodic migraine (EM) without aura.
There is an intriguing hypothesis that sleep deprivation decreases the analgesic effect of distraction in healthy individuals [43], and in the case of migraine, it may accentuate the pattern of altered pain modulation under distracting factors [44].
This study adopted 3D pc-ASL, a novel non-enhancement perfusion sequence to detect the pattern of altered cerebral perfusion in interictal phase of EM in a China headache center.
The pattern of altered gene expression also suggests a depressed maturation of gene expression during onset of auditory function.
The NCT has conducted some proof-of-principle experiments to establish signature profiles of known toxicants and to link the pattern of altered gene expression to specific parameters of conventional indices of toxicity (Hamadeh et al. 2002).
However, you can go still further to analyze in biological terms WHY the pattern of altered miR expression is the way it is, or (stated a different way) to analyze what dimensions are most important for SVM prediction.
The fact that the pattern of altered R2 relaxation rates among the residues in the β4 β5 loop is qualitatively similar upon substituting L119P into FKBP51 compared with substituting P119L into FKBP52 strongly suggests that a similar conformational transition is being affected in both systems.
The similar organismal phenotypes and the overlapping patterns of altered gene expression in tko 25t and sesB led us to question whether the same strategies might be effective in sesB flies.
In summary, we report the expression patterns of altered miRNAs in HCC and the potential role of miR-138 in tumorigenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com