We see in this passage the separation of immediate causes of action, namely pleasure and pain, from the pattern of action serving nature's real end, namely utility.
Compared to the chemotherapy agent Gemcitabine (Figure 5c), the Pattern of Action for Bortezomib shows a more focused hit pattern (Figure 5d).
The first line treatment drug Cisplatin achieved a rank of two (PI = 21.09, see Figure 2a for the Pattern of Action for Cisplatin).
However, the pattern of action was inconsistent between the two antagonists and even with the same antagonist in the presence of different TZDs.
To establish the functional consequence of dopamine depletion on intrinsic electrical properties of MSN, we have characterized the pattern of action potentials evoked in current-clamp recordings by depolarizing pulses applied through the recording pipette at the somatic level.
Cells were characterized based on the pattern of action potentials generated upon somatic current injection and also filled with biocytin, allowing for post hoc identification of their morphological characteristics.
Thus these drug sensitivity associated genes can indicate the key pathways associated with drug efficacy [21] and the overlap of sensitivity associated genes (Fig. 1d) with the baseline inter-module network (Fig. 1e) could highlight the characteristic compound perturbation pattern, which we call the Pattern of Action (POA, Fig. 1f).
We used the merge analysis [ 17] to test which variants under a QTL peak were compatible with the pattern of action at the QTL.
Whereas the average action potential firing frequency was unaffected, loss of surface AMPARs resulted in significant changes in the pattern of action potential firing, likely a result of reduced inhibitory synaptic transmission and an increase in intrinsic neuronal excitability.
As the authors correctly point out, a number of prior studies have used extracellular recordings to show that the pattern of action potentials fired by HVCX neurons is insensitive to perturbations of auditory feedback.
