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Where relatives have felt excluded, we need to ask why doctors were not using the LCP properly, not to attack the pathway itself.
The government-commissioned review, headed by Lady Neuberger, found it was not the pathway itself but poor training and sometimes a lack of compassion on the part of nursing staff that was to blame, while junior doctors were expected to make life-and-death decisions beyond their competence after hours and at weekends.
To address this issue, we introduce a method to systematically expand a pathway by identifying new genes that, from a gene expression perspective, better define the pathway itself.
Thus, adding downstream inhibition in the setting of incomplete upstream target inhibition can result in synergy, even though the pathway itself is linear (Fig. 3C).
Furthermore, it is unclear whether the signaling pathway of DCs stimulated by Ni is different from that of the other stimuli with regard to signal strength or the pathway itself.
Second, the pathway itself was incomplete and far from optimized.
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Multiple mechanisms of endocrine resistance have been proposed, including the deregulation of components of the ER pathway itself, alterations in the cell cycle and cell survival signaling molecules and the activation of escape pathways.
Concerning the treatment pathway itself, we first assessed the pathway content, the participation in the pathway development/ownership, the individual flexibility, and the related effort as relevant aspects for the implementation.
Two miRNAs, miR162 and miR168, are involved in the regulation of the miRNA pathway itself by guiding cleavage of DCL1 and AGO1 mRNAs, respectively.
Little is known about the regulation of the sumoylation pathway itself.
Moreover, the idea that variation in the complement pathway itself might be important in determining the severity of glomerulonephritis has been supported by recent evidence indicating that common genetic variation in the genes encoding complement regulators can affect susceptibility to these diseases in the general population (Gharavi et al., 2011; Zhao et al., 2011).
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