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The observed increment of IL-6 in TTH patients was ascribed to the psychological stress rather than to the pathology itself [19].
Although the pathology itself can be well estimated on otoscopic examination, further questions concerning the extent of the disease, exact location, structures involved and possible bone erosion, will be addressed in detail only with CT and/or MRI.
Current treatments for PE are aimed at normalizing blood pressure rather than targeting the pathology itself, but none is really satisfactory.
However, mechanical ventilation can induce lung injury and thus exacerbate the pathology itself, and it can also contribute to dysfunction of other organs [ 18, 19].
Hyperammonemia symptoms (seizures or neurological dysfunctions) are difficult to differentiate from the pathology itself (epilepsy or bipolar disorder) and they can be misdiagnosed as therapeutic failure instead of an adverse event related to the use of VPA.
Three questions were related to the pathology itself: "do you think influenza A is more severe than seasonal influenza?"; "do you think influenza A is a fatal disease?"; "is there no efficient treatment against influenza A?". Another question was asked in order to quantify the perceived severity.
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Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain.
Reduced activity of the affected leg, both pre- and postoperatively, can contribute to differences (Marchetti et al. 1996)—as can the surgical procedures and the hip pathology itself (Kröger et al. 1996, Martini et al. 2000).
However, disparity between the degree of radiographic structural damage and the severity of symptoms, such as pain and functional limitations in OA patients, implies that factors other than the joint pathology itself, also contribute to the pain.
Nevertheless in this study the authors did not provide information about baseline values of MN; it would have been interesting to know how much the autoimmune pathology itself can contribute to the generation of MN when compared to other inflammatory conditions.
Together with the observations in 3xTg-AD mice, this finding strongly suggests that the primary AD pathology itself diminishes insulin signaling in the brain, and as such, that AD brains are more vulnerable to various pathological insults caused by metabolic impairment or inflammatory responses.
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