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The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1472-6963/12/403/prepub We are extremely grateful to the participating case study organisations for their help, and to individual interviewees for their time and interest in the study.
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Additionally, the proportion of Whites tended to be higher among the participating cases in the published case-control studies compared to the proportion of Whites among the non-participating cases or in cancer registries.
In addition, the participating cases provided blood samples for serological and genetic analyses.
Three of the participating cases were admitted to hospital, of which two were included through the participating academic medical centres.
Of the 1,419 participating cases in this study, 1,012 were women and 407 were men (mean age at inclusion 50 and 53 years, respectively).
The characteristics of participating cases and controls are summarized in Table 1.
The percentage of participating cases with available ER/PR status was at least 65% in nine studies [ 7- 16] 16], whereas it was only 40% in one hospital-based case-control study [ 15].
In a second phase of the study, we retrieved information about histology and various other tumour characteristics from the medical records of all participating cases.
As an additional control, the participating patients' cases were described as vignettes, once without and once with the results of the MSUS examination.
For the control case, the participating physician was asked to check a list of contraindications for two test cases by using the shared EMR only (the control group).
HRQL at baseline was found to be differing between the participating centers (in this case different countries/cultural regions).
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