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For complete list of terms see https://cm.jefferson.edu/downloads/Off-Spotter-code/ Any restrictions to use by non-academics: license needed Off-Spotter described by Pliatsika and Rigoutsos is new software that addresses the paramount problem in the CRISPR-mediated genome engineering, namely identification of off-target sites that might be recognized by a given guide RNA.
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They could have a great and clarifying debate: What exactly are the paramount problems facing the country?
All four enterprises have addressed one of the paramount problems that family businesses often face, the transition from one generation to the other, said Paul Salerno, the center's chairman and a partner in PricewaterhouseCoopers in Melville.
The biobutanol production have gained special attention due to diverse positive characteristics compared with bioethanol, but one of the paramount problems is found at the downstream processes section.
In addition to toxicity, the development of inducible drug resistance is a paramount problem in which patient fails to respond to cancer drugs.
IPV continues to be a paramount problem for Nicaraguan women; however, a considerable proportion of women reported ending abuse.
The authors describe brutality towards women as "a malignancy that is slowly gaining recognition as one of the paramount human rights problems of this century".
He added, "The problem is that young Shiite men will no longer listen to the Marja" — the paramount Shiite clerical authority — "and their political organizations.
The paramount issue is safety.
HUNTINGTON The Paramount Creed, rock.
HUNTINGTON The Paramount Korn, rock.
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