Exact(52)
Several kinetic studies have determined rate constants and equilibrium constants for the elementary steps that make up the overall pathway.
Hence, the overall pathway in the absence of oxygen may be represented as: FeIII pyrite) + H2O → FeII pyrite) + OH + H+ (5).
Redox reactions occur in increments involving 1 or 2 electrons.[10] Thus, the overall pathway of sulfide oxidation must be composed of many steps.
Multivariate modular metabolic engineering, which redefined the overall pathway as a collection of distinct modules, was employed to assess and alleviate pathway bottlenecks.
The overall pathway was firstly divided into four modules and analysis then revealed that efficient conversion of l-phenylalanine to (2S -pinocembrin is the major limiting factor.
A reaction score is calculated based on the Jaccard coefficient for each reaction, and the overall pathway score is the average of the reaction scores of all its reactions.
Similar(7)
These studies identified the putative miRNA targets, but require validation, and the overall pathways have yet to be determined.
A simplified metabolic network based on Bradfield and Nicol [ 15] was used to determine the overall pathways and since the degree of reduction of each carbohydrate is the same, the redox implications will be equivalent for each.
This analysis produced the same set of genes as in Fig. 2 and Additional File 4 apart from a requirement for nuo genes (the large changes in the overall pathways fluxes resulting from deletion of nuo genes were not tolerated by linearMOMA (Additional File 4)).
The robustness of both the estimated P-values of single pathways and the resulting overall pathway ranking increase with the number of random samplings.
Network analysis of this pathway illustrates known interactions between the identified genes and overall pathway downregulation.
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