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The stratified squamous epithelium of the skin forms a barrier between the underlying tissues and the outer milieu to prevent the passage of water and other substances between these compartments.
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Characteristics of good vaccine targets include: (i) expression during infection, (ii) localization to the outer membrane or extracellular milieu, (iii) specificity to many members of the target group (i.e. gene conservation within the group only) and not against beneficial bacteria, and (iv) the ability to trigger a sufficient immunologic response in the host to kill the bacteria.
In this study, we identified 17 potential vaccine targets of the 458 candidate genes that are induced in J2315 under infection-like conditions and that are predicted to be localized in the outer membrane or the extracellular milieu.
The outer layer represents the social, economic, legal and political milieu or the external environment.
The relative dependence of cells on antiapoptotic Bcl-2 proteins is termed mitochondrial priming and changes according to the milieu of Bcl-2 proteins on the outer mitochondrial membrane (OMM) (Del Gaizo Moore and Letai, 2013, Schellenberg et al., 2013).
Annexin-V is a protein that possesses high affinity for phosphatidylserine, a lipid that is translocated to the outer surface of the membrane and exposed to the extracellular milieu, in cells undergoing apoptosis.
What about the outer?
The outer door was open.
So are the Outer Hebrides.
Technical knowledge stops at the outer edge.
Shops and eateries lined the outer perimeter.
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