Optimum questions contributed to the final 34 item questionnaire taken by 261 owners, repeated by 79 two weeks later to assess test-retest reliability.
This is the optimum combination of weighted questions to classify patients as either high or low adherers, and is the function that should be used when implementing the CQR5.
Approaching the question of the optimum size to best relate plot data to remote sensing data, Gobokken and Næsset[63] used a Monte Carlo analysis to explore the optimal size of fixed area plots in developing accurate forest inventory estimates.
Thus, the question of the optimum timing clearly has more than one right answer [ 7].
The Medical Research Council Trial (CR08) (FOCUS- 5-FU, oxaliplatin, CPT-11, use and sequencing) has been designed to address the question of the optimum timing of combination therapies.
Hansen and Wagner [ 10] independently suggested that the relative frequency of synergistic and antagonistic interactions depends on the distance of the genotype in question from the optimum, and thus from the center of the cluster.
Approaching the question of the optimum size to best relate plot data to remote sensing data, Gobokken and Næsset[ 63] used a Monte Carlo analysis to explore the optimal size of fixed area plots in developing accurate forest inventory estimates.
The availability of new drugs poses new questions about the optimum time to give treatment to prevent HCV recurrence, taking into account efficacy, tolerance, and drug drug interactions.
Other issues related to the management of colonised HCW have been raised in the literature, including the questions of the optimum timing of HCW screening and whether and for how long colonised HCWs should be excluded from work [ 6, 13].
The relevance of these risk factors in HPV-positive disease has been questioned and the optimum adjuvant treatment protocols for HPV-positive OPSCC are yet to be determined [ 12].
