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The optimized formulation was characterized by optimal mechanical properties and by cell proliferation and antioxidant activity on human fibroblast cell line.
The optimized formulation was selected through numeric optimization approach.
Considering the data in Table 3 optimization was carried out by Design Expert software and the optimized formulation was suggested as R500 IZn C5,that is, using stirring rate of 500 rpm, Zn ion as the cross-linking agent, and curing time of 5 min.
The optimized formulation was identified and validated for its performance by using numerical optimization technique.
The optimized formulation was calculated and examined.
The optimized formulation was used for cell line studies.
Similar(22)
The practical response values under the optimized formulation were in good accordance with the predicted values.
The morphology, size, physicochemical characterization and in vitro release behavior of the optimized formulation were evaluated.
The in vivo pharmacokinetic parameters of the optimized formulation were compared with the marketed sustained release formulation of atenolol (Aten®).
The pharmacokinetic properties of the optimized formulation were compared with those of two marketed products in rats.
The in vitro drug release, tissue uptake, and in vivo pharmacokinetic study of the optimized formulation were investigated.
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