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The optimization requires varying the configuration of the RF coil system and performing successive calculations of field strength and field homogeneity.
The optimization requires a thorough mechanical characterisation including dynamic tests, with recourse to geophysical techniques, cyclic and monotonic triaxial tests and, ideally, indexed to simple uniaxial compression and indirect tensile tests.
In either case, the optimization requires that the cost and precision be expressed in terms of the sampling design and sample sizes.
For more complex PK/PD models, the calculation may be significantly slower, because each dose calculation involves an optimization (e.g., to assure that plasma concentration is above a certain threshold at a specific timepoint), and each evaluation step in the optimization requires numerical integration of the ordinary differential equations of the model.
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Here, for Isenberg, is the crucial point: Narrowband, closed networks make money precisely by charging for the optimization required by scarce bandwidth.
The alignment-recycling (AR) methodology is intended to obviate performing the optimization required to maximize the volume overlap of the query conformer to each and every conformer in a 3D conformer dataset.
The optimization required about 15,000 core-hours (>600 days of calculations on a single-core computer) and identified another set of parameters (C = 256, γ = 1, ε = 16), which was used for the final analysis.
The optimization required multiple interventions to achieve the best fit.
Networks which robustly reach steady state were rapidly found by our optimization for high a = 0.8: the optimization required 26 iterations to converge, on average (fig. 3a).
Typically, this is chosen so as to optimize the metric clustering and this optimization requires the calculation of the distance matrix for the responses for different values of τ.
However, the corresponding optimization requires the super central-unit having all channel information over the network to control bandwidth allocation, which are impractical in the wireless ad hoc environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com