The simplification is obtained by operating with several designs in different layers, or sequentially, and the optimised result from one layer is brought forward to the next layer.
Optimised results from earlier layers are tested as two-level variables in the top layer, where the low level is a non-optimised solution and the high level is the optimised solution.
Low temperatures (20 °C), high pH values (close to 12), and an oil/ethanol volume ratios of 3.4/1 were found to be the key controlling parameters which provide optimised results after 1 h reaction (conversions around 70%; kinematic viscosities about 8.5 mm2 s−1).
Optimised results are compared with the measured ones and deviation is determined.
Our optimised results show spaces corresponding to the structure nodes in 30.2 nm size for an attenuated phase mask and 9.7 nm for a chromeless phase mask, with less varying profiles for through-focus calculations.
A comparison of optimised results for three working fluids (CO2, ethane, R125) shows that the better fluid depends on the optimised indicator and clearly indicates that a simple first law analysis is not sufficient for the selection of a working fluid.
To provide optimised results to new users, global keywords are applied.
With our optimised results in hand, a thiol nucleophile screen was carried out using allylic alcohols 4 as the model substrate (Table 2).
