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It is, however, not an easy task to achieve the only conformation with the lowest energy among all the potential ones because of the high complexity of the energy landscape and the exponential computation increasing with molecular size.
When starting from the A form on both strands, the only conformation returned reproduces the A-like rotamer and backrub of Ile47.
These data suggest that IFG is a poor transition-state mimic and consistent with this the C1 conformation is the only conformation observed for isofagomine-type inhibitors when bound to mannosidases.
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As a result, the only conformations returned from either starting point (A or B on both strands) represent the original A- and B-like rotamers and backrubs, in that order.
Binding of compound 5 may not bring the complex into the only antagonistic conformation due to the large conformational change of the VDR LBD.
These results together, raise the possibility that the 61 right-handed helical filaments may not be the only functional conformation for RecA family proteins.
The α-helices are not the only helical conformation and are often not linear [7], [8], the β-sheets also show irregularities [9], [10] and the coil is in fact, not strictly random.
As SNP markers are diallelic, the only other conformation encountered was < hk × hk >, where the two parents displayed the same heterozygosity.
The only stable conformation for the misinserted adenine is where it stacks over the templating guanine, but the sugar and base exhibit poor electron density, indicating that the nascent terminus is dynamic.
The apparent dissociation of gL from gH during MuHV-4 entry suggested that the gH-only conformation is functionally important, and therefore that gL has a more complicated role than merely folding gH for cell binding.
The only peptide conformations observed under the conditions investigated were α-helix and random coil.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com