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Aaaand here we have the only charging cable you'll ever need.
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In the case of GLUTs, the only charged residue found in the channel is E396 located in TM10, and it does not possess a salt bridge partner.
In functional Clds, Arg173 (NdCld numbering) represents the only charged amino acid in the heme cavity.
Being the only charged residue in the distal side, R173 was proposed to participate in the chlorite degradation mechanism.
In functional Cld, the only charged amino acid in the distal heme cavity is an arginine (Arg173 in NdCld).
In functional Clds, the distal arginine is the only charged amino acid [ 12], whereas in DyPs a fully conserved aspartate is found at the distal heme cavity.
Because these are the only charged residues close to the nonannular binding sites, they could contribute to fatty acid binding at these sites.
The only charged distal residue in the heme cavity is a conserved and mobile arginine, but its role in catalysis and inactivation is not fully understood.
We have arbitrarily chosen to mutate these two amino acids because they are the only charged amino acid residues of this pentapeptide.
The only charges will be for downloading the data.
But these are not the only charges borrowers face.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com