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From weeks 24 to 52, patients continued with TCZ therapy with blinded MTX or PBO, but open-label conventional (ie, non-biologic) DMARDs could be added, based on disease activity (DAS28>3.2), with the objective of inducing clinical remission (DAS28<2.6).
While these concerns have been addressed [ 9], the objective of inducing prion disease in wild-type animals with rPrP still represents a great challenge.
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In cases where it is necessary to design an early exploratory study to analyze the recommended dose and recommended dosing schedule, the primary objective of inducing a cancer antigen-specific immune response – the cancer peptide vaccine proof of concept – is assumed.
The objective of vaccination is to induce antibodies effective against the current viruses.
The objective of this study was to induce nephrotoxicity in rats with gentamicin and evaluate two miRNA profiling platforms in detecting significant changes in urine samples.
The objective of genotoxic therapy is to induce irreparable genetic damages preferentially in the fast growing cancer cells, so that they will undergo cell death or permanent cell cycle arrest through DDR signalling, thus blocking their ability to divide and to proliferate further [28].
The objective of the 4 experiments was to induce differentiation of the early maturing oocyte in conditions of maintained meiotic arrest or normal maturation.
The objective of regenerative medical therapy is to induce the repair of defective tissues based on the natural healing potential of patients.
The objective of regenerative medical therapy is to induce the regeneration and repair of defective tissues based on the natural healing potential of patients themselves.
Prompted by the anecdotal reports of aminoglycoside-induced selective spiral ganglion damage and the potential of aminoglycosides to induce mistranslation, the objective of this study was to assess the contribution of ER stress to ototoxicity.
However, its ability to induce apoptosis supported the objective of this study, which was to identify agents that demonstrate synergy with ATO in HCC.
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